
Oral cancer is a major global health concern, commonly affecting older males with a history of tobacco and alcohol use. However, a rising incidence in younger populations, particularly females with minimal exposure to traditional risk factors, has been reported. This study aimed to assess the knowledge of oral cancer among adolescent boys in a selected rural area of Jabalpur, evaluate the effectiveness of a structured teaching program (STP) on enhancing their knowledge, and examine the association between post-test knowledge scores and selected demographic variables. A quasi-experimental one-group pretest-posttest design was adopted, with a sample of 60 adolescent boys aged 10–17 years. Pretest knowledge scores were collected (O1), followed by a 45-minute STP using audiovisual aids (X), and post-test scores were measured (O2). Results indicated that structured teaching significantly improved knowledge regarding oral cancer prevention, risk factors, and early signs. While dietary pattern showed a significant association with knowledge levels, variables such as age, source of information, and education did not. The study highlights the importance of targeted educational interventions in increasing awareness among adolescents.