2025, Vol. 7, Issue 2, Part C

Background: Peptic ulcer disease (PUD) remains a significant global health concern despite advances in pharmacotherapy and endoscopic management. While Helicobacter pylori eradication and proton pump inhibitors (PPIs) have reduced recurrence, persistent challenges such as treatment nonadherence, NSAID overuse, and bleeding complications underscore the importance of patient-centered nursing interventions.

Objective: This review synthesizes recent evidence (2010-2025) on the effectiveness of patient-centered nursing care strategies in optimizing peptic ulcer management, focusing on education, adherence, peri-endoscopic care, medication stewardship, and holistic recovery.

Methods: A hybrid systematic-narrative review approach was employed using PubMed, CINAHL, Scopus, Web of Science, and Cochrane databases. Eighteen studies meeting inclusion criteria RCTs, quasi-experimental trials, systematic reviews, and guidelines were appraised using JBI, CASP, and AMSTAR-2 tools.

Results: Evidence demonstrates that structured nursing education improves adherence to H. pylori eradication therapy by 20-25%, reducing recurrence and enhancing quality of life. Nurse-led peri-endoscopic and postoperative interventions shortened hospital stays and improved bleeding control. Telehealth and follow-up programs increased medication adherence (92% vs 70%) and reduced readmissions. Nursing-led PPI deprescribing initiatives and NSAID risk assessments promoted safe, rational pharmacotherapy. Overall, patient-centered interventions consistently enhanced satisfaction, safety, and self-management outcomes across diverse settings.

Conclusion: Patient-centered nursing care is pivotal in improving adherence, safety, and holistic recovery in PUD management. Integrating structured education, digital follow-up, and medication stewardship within nursing workflows can substantially improve both clinical and patient-reported outcomes.