Stevens-Johnson syndrome (SJS) is a hypersensitivity reaction that affects the skin and mucous membranes. In this case report the patient had drug induced hypersensitivity reaction after taking treatment for bilateral leg edema, was hospitalized and later diagnosed as SJS. Upon evaluation, the patient had increased serum creatinine, decreased albumin, decreased urinary output almost an uric and bilateral leg edema which are the signs of acute kidney injury (AKI), a common complication of SJS/TEN. The patient was treated with fluid replacement, wound dressing, Incision and drainage of abscess in left thigh and leg, Necrotic spatches were removed by wound debridement. Further the patient needed split skin graft for left leg and thigh but due to her age and general condition, the surgery was deferred. She was discharged with the follow up advice.